Plasma cholesterol lowering action of bile acid binding polymers in experimental animals.

Feeding of bile acid binding polymeric organic bases inhibited cholesterol rise and aortic. plaque formation in cholesterol-fed cockerels, lowered plasma cholesterol concentrations in normocholesterolemic cockerels and dogs, and increased fecal bile acid and sterol output in a dog. In experiments lasting as long a~ one year these substances have not produced visible toxic effects. They are thought to act by binding the bile acids in the intestinal tract.